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. 2007 Feb 12;51(5):1666–1670. doi: 10.1128/AAC.01303-06

TABLE 6.

Frequency of resistance to EDP-420 and EDP-420/mefloquine

Experimental group Mice (n) CFU/g of spleen Frequency of resistance to EDP-420
8 week control 24 7.0 × 109 ± 1.6 × 109 ∼10−9
8 week EDP-420 27 2.3 × 105 ± 0.8 × 105 Undetected
8 week EDP-420 + mefloquine 22 1.2 × 105 ± 0.3 × 105 Undetected
12 week control 21 4.6 × 109 ± 1.5 × 109 ∼10−9
12 week EDP-420 27 2.5 × 105 ± 1.1 × 105 Undetected
12 week EDP-420 + mefloquine 20 1.1 × 105 ± 0.5 × 105 Undetected