TABLE 6.
Experimental group | Mice (n) | CFU/g of spleen | Frequency of resistance to EDP-420 |
---|---|---|---|
8 week control | 24 | 7.0 × 109 ± 1.6 × 109 | ∼10−9 |
8 week EDP-420 | 27 | 2.3 × 105 ± 0.8 × 105 | Undetected |
8 week EDP-420 + mefloquine | 22 | 1.2 × 105 ± 0.3 × 105 | Undetected |
12 week control | 21 | 4.6 × 109 ± 1.5 × 109 | ∼10−9 |
12 week EDP-420 | 27 | 2.5 × 105 ± 1.1 × 105 | Undetected |
12 week EDP-420 + mefloquine | 20 | 1.1 × 105 ± 0.5 × 105 | Undetected |