TABLE 3.

Rectally applied UC781 gel safety study design^a

Procedure or measurement	Procedure or measurement performed at the following timeb:
	Day 1		Day 2		Day 3		Day 4		Day 5 (follow-up)
	0 min	30 min	0 min	30 min	0 min	30 min	0 min	30 min
Blood draw	X	X		X		X		X	X
Microflora	X		X		X		X		X
Rectal pH	X	X	X	X	X	X	X	X	X
Rectal cytokines	X		X		X		X		X
Rectal lavage	X	X	X	X	X	X	X	X	X

^aAfter each sampling at 0 min, 2.5 ml UC781 or HEC gel was applied intrarectally.

^bAn X indicates that the procedure or measurement was performed (e.g., blood was drawn at 0 and 30 min on day 1, at 30 min on days 2, 3, and 4, and on day 5 [follow-up]). Blood was drawn, and swabs were taken for assessment of microflora, rectal pH, and rectal cytokines 30 min after application of the gel.