TABLE 2.
Fitted amprenavir pharmacokinetic parameters with summary statistics
| Parametera | Mean | Median | Interquartile range |
|---|---|---|---|
| Vc/F (liters/kg) | 1.07 | 0.987 | 0.704-1.35 |
| Vp/F (liters/kg) | 7.65 | 5.61 | 2.39-11.8 |
| CLd (liters/h/kg) | 0.426 | 0.320 | 0.225-0.484 |
| CLt/F (liters/h/kg) | 1.17 | 0.917 | 0.680-1.40 |
| CLb/F (liters/h/kg) | 0.106 | 0.090 | 0.051-0.144 |
| Fraction recycled | 0.079 | 0.065 | 0.042-0.103 |
| Recycling time (h) | 7.88 | 7.89 | 7.42-8.28 |
| TLag (h) | 0.354 | 0.013 | 0.006-0.799 |
| ka (h−1) | 0.986 | 0.995 | 0.823-1.08 |
| kel (h−1) | 1.209 | 0.963 | 0.691-1.39 |
| kcp (h−1) | 0.496 | 0.363 | 0.203-0.546 |
| kpc (h−1) | 0.124 | 0.059 | 0.036-0.133 |
| α t1/2 (h) | 0.547 | 0.520 | 0.341-0.724 |
| β t1/2 (h) | 15.8 | 21.0 | 7.54-27.5 |
a
Vc, apparent volume of central compartment; F, systemic bioavailability; Vp, apparent volume of the peripheral compartment; CLd, distributional clearance; CLt, total APV clearance; CLb, clearance to the recycling compartment; TLag, lag time; ka, first-order rate constant of absorption; kel, elimination rate constant; kcp, elimination rate constant from central compartment to peripheral; kpc, elimination rate constant from peripheral compartment to central; α t1/2, distribution half-life; β t1/2, elimination half-life.