TABLE 4.

Efficacy of dalbavancin against S. pneumoniae and S. aureus

Regimen and organism	MIC (mg/liter)	MIC/MBC (mg/liter)	Static effect			1-log killing			2-log killing
			Dose (mg/kg/24 h or mg/kg/72 h)	Free-drug 24-h AUC/MIC	Free-drug 24-h AUC/MBC	Dose (mg/kg/24 h or mg/kh/72 h)	Free-drug 24-h AUC/MIC	Free-drug 24-h AUC/MBC	Dose (mg/kg/24 h or mg/kh/72 h)	Free-drug 24-h AUC/MIC	Free-drug 24-h AUC/MBC
q24h regimen
S. pneumoniae
1199	0.004		0.40	16.0		0.49	19.4		0.57	22.7
1293	0.004		0.44	17.4		0.55	21.7		0.65	25.9
1325	0.008		1.46	29.0		1.6	31.8		1.73	34.5
1329	0.008		0.90	18.0		1.18	23.5		1.45	26.7
ATCC 10813	0.03		1.34	7.5		1.54	8.7		1.75	9.9
Mean ± SD			0.91 ± 0.44	17.6 ± 6.9		1.1 ± 0.47	21 ± 7.4		1.23 ± 0.52	24.3 ± 8.2
S. aureus
ATCC 25923		0.12/0.50	42.7	216	52	51.2	250	60	60	289	69.3
33591		0.12/0.25	22.3	96.2	46	27.7	121	58.3	33.5	157	74.3
31005		0.06/0.12	49.3	483	242
MRSA		0.06/0.25	37.7	374	93	45.3	452	109	53.5	519	125
Smith		0.12/0.25	33.5	156	75	50.7	248	119	73.5	361	173
Mean ± SD			37.1 ± 9.1	265 ± 143	101 ± 72	43.7 ± 9.5	268 ± 119	86.6 ± 27.6	55 ± 14	332 ± 131	110 ± 42
q72h regimen
S. pneumoniae
1325	0.008		0.83	6.0		0.99	8.8		1.16	17.6
1293	0.004		1.01	14.1		1.28	18		1.68	23.8
1199	0.004		0.72	10.3		0.85	12.1		0.99	35.3
1396	0.008		0.52	4.0		0.61	4.3		0.69	4.8
ATCC 10813	0.03		0.71	1.4		0.77	1.6		0.82	1.6
Mean ± SD			0.77 ± 0.18	7.2 ± 4.5		0.93 ± 0.24	9.0 ± 5.8		1.13 ± 0.36	16.6 ± 12.3
S. aureus
ATCC 25923		0.12/0.50	160	274	66	185	317	76.1	214	367	88.1
33591		0.12/0.25	74	123	59	93	160	76.6	114	195	94
MRSA		0.06/0.25	43	147	35.3	62	202	48.8	85	292	70
Smith		0.12/0.25	59	96	46.1	95	163	78.0	148	254	22
307109		0.06/0.50	31	94	11.3	34	108	12.9	37	121	14.6
31005		0.06/0.12	67.7	223	112	94.6	325	163	127	364	217
Mean ± SD			72 ± 41	160 ± 67	55 ± 31	94 ± 46	213 ± 81.4	75.9 ± 45.2	120 ± 54	266 ± 88	101 ± 61