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. 2007 Mar 12;51(5):1844–1848. doi: 10.1128/AAC.01428-06

FIG. 1.

FIG. 1.

Effect of miltefosine on cultures of several streptococcal species. Exponentially growing cultures were incubated in THY broth to an A550 of about 0.2. Miltefosine was then added to a portion of the culture, and incubation was continued without shaking at 37°C. Panels: A, S. pneumoniae R6; B, S. pneumoniae Spain23F-1; C, S. pneumoniae 8249; D, S. pseudopneumoniae type strain; E, Streptococcus sp. strain 789/96; F, Streptococcus sp. strain 11923/96; G, S. pyogenes type strain; H, S. agalactiae type strain; I, S. mutans type strain; J, S. sanguinis type strain. Solid circles represent untreated control cultures. Miltefosine was added at the following concentrations: ⋄, 25 μM; ○, 10 μM; □, 5 μM; ▵, 2.5 μM. The chemical structure of miltefosine is shown at the top.