TABLE 2.
Pharmacodynamic effects of polymyxin B and tigecycline plus polymyxin B against CIRA
| Expt no. | Polymyxin B (2 mg/liter)
|
Tigecycline (0.125 mg/liter) + polymyxin B (2 mg/liter)
|
Interpretation | ||||
|---|---|---|---|---|---|---|---|
| Log10 CFU/ml at time zero | Log10 CFU/ml at time 24 h | Change in log10 CFU/ml from time zero to 24 h | Log10 CFU/ml at time zero | Log10 CFU/ml at time 24 h | Change in log10 CFU/ml from time zero to 24 h | ||
| 1 | 5.52 | 3.95 | −1.57 | NAa | NA | NA | NA |
| 2 | 5.20 | 1.60 | −3.6 | 5.44 | 3.99 | −1.45 | Antagonism |
| 3 | 5.20 | 4.64 | −0.56 | 5.01 | 1.60 | −3.41 | Enhancement |
| 4 | 5.30 | 6.34 | +1.04 | 5.26 | 1.60 | −3.65 | Bactericidal |
| 5 | 5.36 | 2.20 | −3.16 | 5.44 | 5.76 | +0.32 | Antagonism |
a
NA, not applicable.