Upper pathway for catabolism of biphenyls encoded by the bph locus of B. xenovorans LB400. Compounds: 1, biphenyl; 2, biphenyl-2,3-dihydro-2,3-diol (BDHD); 3, 2,3-dihydroxybiphenyl (DHB); 4, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA); 5a, 2-hydroxypenta-2,4-dienoic acid; 5b, benzoic acid. Enzymes: BphA, biphenyl 2,3-dioxygenase; BphB, 2,3-dihydro-2,3-dihydroxybiphenyl 2,3-dehydrogenase; BphC, 2,3-dihydroxybiphenyl 1,2-dioxygenase; BphD, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase.