Table 2.
Ratios of dopamine uptake inhibition potency-to-binding affinity constants for DAT ligands at WT DAT CHO cells as a function of cell passage number
DUIP:Affinity Ratio Cell Passage | |||
---|---|---|---|
Low | Medium | High | |
Cocaine | 4.0 | 5.3 | 5.9 |
Mazindol | 2.9 | 3.8 | 4.7 |
Methylphenidate | 4.8 | 8.8 | 7.8 |
Benztropine | 3.0 | 4.6 | 4.5 |
(+)-Amphetamine | 1.3 | 1.6 | 1.6 |