TABLE 3.

Genes differentially expressed in the cg1486 mutant C. glutamicum IB1486

Gene identifiera	Gene	Gene product or deduced functionb	M value	A value	P value
cg1488	leuD	Isopropylmalate dehydratase, small subunit	4.58	12.58	7.87 × 10−8
cg1487	leuC	Isopropylmalate dehydratase, large subunit	4.35	11.93	5.25 × 10−8
cg1413	rbsB	ABC-type ribose transporter, substrate-binding protein	3.48	10.97	1.44 × 10−7
cg1412	rbsC	ABC-type ribose transporter, permease subunit	2.92	10.67	3.27 × 10−10
cg1658		Putative MFS-type permease	2.88	10.70	5.43 × 10−12
cg1453	leuB	Isopropylmalate dehydrogenase	2.75	12.32	4.31 × 10−11
cg1411	rbsA	ABC-type ribose transporter, ATPase subunit	2.70	10.50	1.24 × 10−8
cg1129	aroF	Phospho-2-dehydro-3-deoxyheptonate aldolase	2.42	10.83	6.96 × 10−3
cg2893		Putative MFS-type permease	2.25	10.94	2.33 × 10−3
cg1410	rbsR	ABC-type ribose transporter, transcriptional repressor	2.18	10.16	5.67 × 10−9
cg2391	aroG	3-Deoxy-7-phosphoheptulonate synthase	1.59	12.44	4.06 × 10−8
cg3359	trpE	Anthranilate synthase, subunit I	1.57	11.44	2.90 × 10−6
cg2894		Putative transcriptional regulator, TetR family	1.56	12.55	4.97 × 10−4
cg1612		Putative acetyltransferase	1.50	11.50	4.47 × 10−3
cg3362	trpCF	Phosphoribosylanthranilate isomerase	1.50	10.92	2.23 × 10 −5
cg2565		Hypothetical protein	1.47	10.97	8.33 × 10−3
cg3361	trpD	Anthranilate phosphoribosyltransferase	1.43	10.68	2.96 × 10−6
cg1419		Putative secondary transporter	1.42	12.46	2.09 × 10−5
cg2610		Putative ABC-type transporter, substrate-binding protein	1.40	12.21	4.28 × 10−4
cg3360	trpG	Anthranilate synthase, subunit II	1.36	10.64	2.87 × 10−6
cg2837	sucC	Succinate-CoA ligase (ADP-forming), beta subunit	1.34	13.44	2.76 × 10−3
cg2137	gluB	ABC-type glutamate transporter, substrate-binding protein	1.30	14.43	4.51 × 10−9
cg2836	sucD	Succinate-CoA ligase (ADP-forming), alpha subunit	1.30	12.93	2.98 × 10−4
cg0303	leuA	Isopropylmalate synthase	1.30	12.55	3.94 × 10−3
cg3047	ackA	Acetate kinase	1.30	10.58	3.39 × 10−5
cg2138	gluC	ABC-type glutamate transporter, permease subunit	1.19	13.05	1.78 × 10−6
cg2559	aceB	Malate synthase	1.18	10.49	2.02 × 10−5
cg2136	gluA	ABC-type glutamate transporter, ATPase subunit	1.17	14.36	3.41 × 10−9
cg0961		Putative hydrolase	1.17	11.05	3.83 × 10−4
cg3096		Putative aldehyde dehydrogenase	1.15	13.31	1.17 × 10−3
cg3022		Hypothetical protein	1.15	11.95	1.62 × 10−3
cg2636	catA	Catechol 1,2-dioxygenase	1.13	11.76	4.94 × 10−4
cg2118		Putative transcriptional regulator, DeoR family	1.12	10.72	5.65 × 10−7
cg2630	pcaG	Protocatechuate 3,4-dioxygenase, alpha subunit	1.11	11.14	1.20 × 10−3
cg1084	cgtR10	Two-component system, response regulator	1.11	11.04	2.27 × 10−7
cg1615		Putative pseudouridylate synthase	1.10	11.61	4.13 × 10−3
cg1616	cmk	Cytidylate kinase	1.09	12.03	1.52 × 10−3
cg2937		Putative ABC-type transporter, substrate-binding protein	1.09	10.65	1.89 × 10−6
cg1617		Putative GTPase of unknown function	1.03	12.40	8.37 × 10−3
cg1085		Hypothetical protein	1.01	14.03	3.39 × 10−3
cg3329		Hypothetical protein	1.01	10.62	2.13 × 10−2
cg3363	trpB	Tryptophan synthase, beta chain	1.00	10.56	1.97 × 10−5
cg2102	sigB	RNA polymerase, sigma factor B subunit	−1.02	12.76	8.39 × 10−9
cg2657		Putative membrane protein	−1.03	11.72	8.52 × 10−6
cg3309		Putative secreted protein	−1.07	11.09	1.54 × 10−5
cg2651		Hypothetical protein	−1.14	12.68	5.97 × 10−8
cg1121		Putative MFS-type permease	−1.15	12.29	3.37 × 10−10
cg0756	cstA	Carbon starvation protein A	−2.57	11.08	2.49 × 10−6
cg2545		Putative secreted or membrane protein	−4.07	11.52	3.55 × 10−7
cg2546		Putative secondary C4-dicarboxylate transporter	−4.46	12.08	5.56 × 10−9

^aGenes specifically labeled in Fig. 2 are in bold.

^bCoA, coenzyme A.