Table 1.
antibody | epitopea | positionb | blockingC (μg/ml) | referenced |
100B3 | KRPKP | 26–30 | ~0,5 | Thuring, 2005 [30] |
SAF32 | QPHGGGW e | 54–92 | 25,0 | Feraudet, 2005 [51] |
9A2 | WNK | 102–104 | 4,0 | Langeveld, 2006 [47] |
6C2 | HVAGAAA | 114–120 | 20,0 | this paper |
6H4 | DYEDRYYRE | 147–155 | 1,0 | Korth, 1997 [18] |
94B4 | HTVTTTTK | 190–197 | 10,0 | Thuring, 2004 [52] |
M7 | QQSYGQEP | n.a. | n.a. | Bakker, pers. comm. |
a amino acid sequence of the reported antibody epitope using peptide mapping techniques
b position of the antibody epitope(s) in the ovine protein sequence
c concentration at which the antibody completely blocked binding on the peptide-array
d publication in which the epitope mapping results are reported
e epitope of octarepeat (partially); occurs as 5 respectively 6 successive sequences in ovine and bovine PrP