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. 2007 May 9;2(5):e431. doi: 10.1371/journal.pone.0000431

Figure 6. Effect of imipramine on stress-induced CREB phosphorylation.

Figure 6

Male CRE-Luc mice were exposed to chronic psychosocial stress with or without concurrent imipramine treatment for 21 days. Homogenates of whole brains were submitted to immunoblotting using specific CREB and phospho-CREB antibodies. Intensity of specific bands was determined densitrometrically and ratios between CREB and phospho-CREB were calculated. Solvent-treated littermates served as controls. Values are means±SEM from 5 animals. Significant difference: *:p<0.05; Kruskal-Wallis test followed by Schaich Hamerle-post hoc test.