Table 2. Luciferase activity in imipramine-treated CRE-Luc mice.

	Acute treatment (24 h)		Chronic treatment (21 d)
	Control	Imipramine	Control	Imipramine
Bulbus	100±20.9	156.6±16.0	100±9.5	78.0±25.0
Cerebellum	100±33.6	162.7±31.5	100±9.3	100.2±15.0
Pons	100±34.2	142.3±50.9	100±11.2	70.2±9.1
Colliculi	100±53.0	197.1±53.9	100±8.6	80.8±10.9
Hippocampus	100±25.5	115.3±31.4	100±20.6	48.4±6.3*
Hypothalamus	100±34.7	113.4±25.5	100±20.1	85.0±18.6
PFC	100±33.9	82.2±31.2	100±9.7	83.8±9.3
Cortex	100±29.1	105.0±36.1	100±11.8	74.5±9.5

Acute and chronic treatment with imipramine was performed in CRE-Luc mice that were not stressed. PFC: prefrontal cortex. Values are percentage of the mean value in controls (solvent-treated littermates) (±SEM) from 3 (acute) and 12 (chronic) animals per group.