Table 3. Salt-induced changes in blood pressure, and baseline P-renin and Nt-proANP in different genotype carriers.
| rs4149601 GG+rs2288774 CC/CT genotype variants vs non-carriers | |||
| GG+CC/CT (n = 11) | Non-carriers (n = 28) | P-value | |
| Δ24SBP(mmHg) | 8.0(6.0–18) | 5.0(0.0–10) | 0.067 |
| Δ24DBP(mmHg) | 2.0(−1.0–11) | 2.0(−1.0–5.75) | 0.158 |
| ΔDSBP(mmHg) | 8.0(4.0–19) | 5.0(−2.0–8.75) | 0.058 |
| ΔDDBP(mmHg) | 4.0(−3.0–11) | 1.5(−1.0–3.75) | 0.140 |
| ΔNSBP(mmHg) | 14.0(2.0–15) | 5.5(0.0–9.0) | 0.083 |
| ΔNDBP(mmHg) | 8.0(1.0–10) | 4.0(−2.75–7.0) | 0.124 |
| P-renin(mU/L) | 9.0(6.0–16) | 15.0(9.0–28.0) | 0.030 |
| Nt-proANP(pmol/L) | 754(426–880) | 493(422–622) | 0.109 |
| rs4149601 GG+rs2288774 CC genotype vs non-carriers | |||
| GG+CC (n = 5) | Non-carriers (n = 34) | P-value | |
| Δ24SBP(mmHg) | 18(7.5–20) | 6.0(0.0–10) | 0.007 |
| Δ24DBP(mmHg) | 9.0(0.5–13.5) | 1.5(−1.25–6.0) | 0.081 |
| ΔDSBP(mmHg) | 19(5.0–21.5) | 5.0(−2.0–9.0) | 0.024 |
| ΔDDBP(mmHg) | 9.0(0.0–13.5) | 1.5(−1.0–4.0) | 0.117 |
| ΔNSBP(mmHg) | 15.0(12.5–20) | 5.0(−0.25–9.5) | 0.001 |
| ΔNDBP(mmHg) | 8.0(4.5–11) | 4.0(−2.0–7.0) | 0.089 |
| P-renin(mU/L) | 6.0(2.0–9.5) | 15.0(9.0–24.0) | 0.005 |
| Nt-proANP(pmol/L) | 806(590–1186) | 493(417–655) | 0.031 |
Blood pressure change in low versus (vs) high salt intake; Δ24SBP, delta 24-hour systolic blood pressure; Δ24DBP, delta 24-hour diastolic blood pressure; ΔDSBP, delta daytime systolic blood pressure; ΔDDBP, delta daytime diastolic blood pressure; ΔNSBP, delta night-time systolic blood pressure; ΔNDBP; delta night-time diastolic blood pressure. P-value<0.05 is considered statistically significant. Numbers represent Median(Inter Quartile Range).