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Possible conformations of the protein X binding site used to create a data set of pharmacophores. In the first conformation, residue 168 is positioned as found in the NMR structure of PrP(90–231) whereas in the second one, helix B is extended to residue V166 (25). In this case, residue Q168 forms a contiguous structural epitope with the other three protein X binding site residues, Q172, T215, and Q219.
