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. 2006 Oct 17;66(3):377–388. doi: 10.1136/ard.2006.062091

Table 5 Future research agenda.

No Proposition
1 Clinical trials on hand OA should separately consider the localisation (thumb base, interphalangeal joints) and the stage or type of OA (non‐erosive, erosive, nodal) and examine clinical predictors of response
2 Thorough evaluation is required of physical treatments, such as ultrasound, laser, TENS, and local application of heat (for example, paraffin wax, hot pack)
3 Studies are required to determine the most appropriate form or combination of exercise (for example, strengthening, range of movement) for the different subsets of hand OA
4 Further studies are required to better evaluate the symptom and structure modifying effects of SYSADOA
5 The benefits of intra‐articular injection of either corticosteroid or hyaluronan should be determined both for thumb base and interphalangeal OA
6 Existing slow acting antirheumatic drugs and biological agents (especially anti‐tumour necrosis factor therapy) should be investigated in erosive interphalangeal OA, to determine possible symptom benefits and structure modifying effects
7 The efficacy and safety (both short and long term) of paracetamol, weak opioids, and oral NSAIDs need to be assessed and compared
8 The potential benefits of surgery compared with conservative management, and the most appropriate surgical procedure for thumb base OA, remain to be determined