Table 1 Genotypic/allelic frequencies of tumour necrosis factor α promoter polymorphisms in patients with ankylosing spondylitis and controls.
| Subjects | G−238A | G−308A | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotypes | p Value | Alleles | p Value | Genotypes | p value | Alleles | p value | |||||||
| G/G | A/G | A/A | G | A | G/G | A/G | A/A | G | A | |||||
| Control (n = 112) | 104 (92.9) | 8 (7.1) | 0 (0) | 0.007 | 216 (96.4) | 8 (3.6) | 0.007 | 84 (75.0) | 25 (22.3) | 3 (2.7) | 0.045 | 193 (86.2) | 31 (13.8) | 0.018 |
| AS (n = 143) | 142 (99.3) | 1 (0.7) | 0 (0) | 285 (99.6) | 1 (0.4) | 121 (84.6) | 22 (15.4) | 0 (0) | 264 (92.3) | 22 (7.7) | ||||
| B27+ AS | ||||||||||||||
| B60+ (n = 29) | 29 (100) | 0 (0) | 0 (0) | NA | 58 (100) | 0 (0) | NA | 29 (100) | 0 (0) | 0 (0) | 0.010 | 58 (100.0) | 0 (0.0) | 0.012 |
| B60− (n = 48) | 48 (100) | 0 (0) | 0 (0) | 96 (100) | 0 (0) | 39 (81.2) | 9 (18.8) | 0 (0) | 87 (90.6) | 9 (9.4) | ||||
AS, ankylosing spondylitis; NA, not available; +, positive.