Figure 2 Intestinal permeability in Crohn's disease first degree relatives without a CARD15 mutation (CD‐R WT) and with 3020insC or 3020insC‐R702W mutations (CD‐R 3020insC). Intestinal permeability was significantly increased in CD‐R with mutations compared with CD‐R without mutations. PI, permeability index (lactulose (Lac)/mannitol (Man) ratio). ***p = 0.001 between the CD‐R WT and CD‐R 3020insC groups (Mann‐Whitney test). Broken line indicates the upper limit of normal permeability. Data are presented as box plats.