Table 2 Prevalence of CARD15 mutations.

Genotype	Control	CD	CD‐R	CD‐NR
3020insC	(n = 62)	(n = 121)	(n = 106)	(n = 50)
Wild‐type	98% (61)	78% (94)	77% (82)	88% (44)
Heterozygous mutant	2% (1)	18% (22)	22% (23)	10% (5)
Homozygous mutant		4% (5)	1% (1)	2% (1)
		p<0.0005	p<0.0005	p = 0.044
R702W	(n = 62)	(n = 120)	(n = 106)	(n = 50)
Wild‐type	94% (58)	83% (100)	84% (89)	88% (44)
Heterozygous mutant	6% (4)	14% (17)	15% (16)	12% (6)
Homozygous mutant		3% (3)	1% (1)
		p = 0.06	p = 0.091	p = 0.337
G908R	(n = 62)	(n = 120)	(n = 105)	(n = 50)
Wild‐type	97% (60)	92% (110)	98% (103)	98% (49)
Heterozygous mutant	3% (2)	8% (10)	2% (2)	2% (1)
		p = 0.343	p = 0.628	p = 1.000
Overall	(n = 62)	(n = 121)	(n = 106)	(n = 50)
	11% (7)	43% (52)	37% (39)	24% (12)

CD, Crohn's disease; CD‐R, first degree relative of a patient with CD; CD‐NR, non‐related household member living with a patient with CD.

Overall, number of persons carrying at least one mutation.

p values for differences in frequency distribution of CARD15 mutations between CD groups and controls (Fisher's exact test)

Number of cases in parentheses.