Table 2 Apolipoprotein E (APOE) genotype distribution in patients with spontaneously resolved infection (HCV RNA negative cleared infection) versus chronic infection (HCV RNA positive chronic infection).

APOE genotype	Chronic HCV infection (n = 312)	Cleared HCV infection (n = 108)	GRR (95% CI)	p Value
E2,E2	0	0	–	–
E2,E3	23 (7.5%)	16 (15%)	0.36 (0.18–0.73)	0.005
E2,E4	4 (1%)	5 (4%)	0.20 (0.52–0.77)	0.020
E3,E3	210 (67.5%)	53 (49%)	1	–
E3,E4	72 (23%)	33 (31%)	0.55 (0.33–0.92)	0.022
E4,E4	3 (1%)	1 (1%)	0.76 (0.77–7.42)	NS

Values are number (%).

HCV, hepatitis C virus; GRR, genotype relative risk; 95% CI, 95% confidence interval.