Table 2 Hazard ratios (HR) and 95% confidence interval (95% CI) for colorectal cancer specific survival for all cases, the physically inactive, and the physically active, adjusted for stage (categorical), degree of differentiation (categorical), age and sex, per cent fat, and body mass index.
| HR (95% CI) comparing quartile of plasma level with quartile 1 | HR per increase of 1 SD in hormone level | |||
|---|---|---|---|---|
| Q2 | Q3 | Q4 | ||
| All cases | ||||
| IGF‐1 per SD | 1.29 (0.80–2.08) | 1.17 (0.72–1.89) | 0.95 (0.58–1.55) | 0.95 (0.80–1.14) p = 0.59 |
| IGFBP‐3 per SD | 0.86 (0.53–1.39) | 0.97 (0.61–1.56) | 0.70 (0.43–1.14) | 0.87 (0.74–1.03) p = 0.11 |
| Physically inactive | ||||
| IGF‐1per SD | 1.34 (0.74–2.45) | 1.06 (0.57–1.95) | 1.57 (0.86–2.84) | 1.13 (0.92–1.39) p = 0.24 |
| IGFBP‐3 per SD | 1.07 (0.59–2.00) | 1.30 (0.71–2.36) | 1.26 (0.68–2.35) | 1.08 (0.88–1.33) p = 0.45 |
| Physically active | ||||
| IGF‐1per SD | 0.69 (0.28–1.68) | 0.89 (0.35–2.16) | 0.30 (0.11–0.81) | 0.59 (0.41–0.86) p = 0.006 |
| IGFBP‐3 per SD | 0.42 (0.18–1.00) | 0.43 (0.18–1.04) | 0.17 (0.07–0.44) | 0.49 (0.33–0.77) p<0.001 |
Standard deviation (SD) for insulin‐like growth factor 1 (IGF‐1) is 8.5 nmol/l; SD for insulin‐like growth factor binding protein 3 (IGFBP‐3) is 26.2 nmol/l.
Quartiles are based on all 443 cases.