Table 2 HFE genotype and haematology for 282 first degree relatives of C282Y homozygous probands.
| Genotype (C282Y/H63D) | Parents (%) (n = 92) | Siblings (%) (n = 189) | Hb (g/dl) | MCV (fl) | MCH (pg) |
|---|---|---|---|---|---|
| −−/−− | 0 | 38 (20.1) | 14.0 (1.00) | 90 (5) | 30.0 (2.0) |
| −−/+− | 0 | 20 (10.6) | 14.2 (1.52) | 89 (7) | 29.9 (2.6) |
| −−/++ | 0 | 2 (1.1) | 13.8 (0.85) | 88 (1) | 29.7 (0.3) |
| +−/−− | 68 (73.9) | 65 (34.4) | 14.1 (1.42) | 91 (5) | 30.3 (2.0) |
| +−/+− | 15 (16.3) | 14 (7.4) | 14.6 (1.50) | 93 (6) | 31.3 (2.3)* |
| ++/−− | 9 (9.8) | 50 (26.4) | 14.3 (1.59) | 94 (5)*** | 31.5 (1.8)*** |
Measurements are given as mean (SD).
Hb, haemoglobin; MCV, mean corpuscular volume; MCH, mean cell haemoglobin.
Comparisons of blood parameters were made between individual genotypes and wild‐type genotype (−−/−−).
*p⩽0.05, ***p⩽0.001.
Note: data for one parent had to be omitted as DNA analysis revealed non‐paternity.