Figure 6 Effects of cyclooxygenase 2 (COX‐2) inhibitors on severity of rat oesophagitis. The COX‐2 inhibitors celecoxib (10 mg/kg/day) and nimesulide (10 mg/kg/day) did not affect acute oesophageal lesions (day 3) but significantly reduced the severity of chronic oesophagitis (day 21). Values are mean (SD) of 6–8 experiments. *p<0.001 versus control on day 21. Control = vehicle treated group.