Table 2 Overall cause specific mortality for all patients (age, sex, and country adjusted), according to sex (age and country adjusted), age (sex and country adjusted), disease location and behaviour at diagnosis (age, sex, and country adjusted), and residence (age and sex adjusted).
| No | Cancer | Cardiovascular causes | Pulmonary causes | Gastrointestinal causes | All causes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CCS ICD‐10: 011–044 | CCS ICD‐10: 099–118 | CCS ICD‐10: 122–134 | CCS ICD‐10: 138–155 | CCS ICD‐10: 1–259 | |||||||||||||
| Dead | Exp | SMR (95%CI) | Dead | Exp | SMR (95%CI) | Dead | Exp | SMR (95%CI) | Dead | Exp | SMR (95%CI) | Dead | Exp | SMR (95%CI) | |||
| All patients | 371 | 11 | 5.60 | 1.96 (0.98–3.51) | 11 | 7.39 | 1.49 (0.74–2.66) | 4 | 1.50 | 2.66 (0.72–6.80) | 8 | 0.82 | 9.77 (4.20–19.2) | 37 | 21.5 | 1.85 (1.30–2.55) | |
| Sex | |||||||||||||||||
| Male | 183 | 8 | 3.43 | 2.33 (1.00–4.59) | 4 | 4.17 | 0.96 (0.26–2.46) | 3 | 0.83 | 3.61 (0.73–10.6) | 5 | 0.50 | 10.0 (3.23–23.4) | 21 | 11.6 | 1.79 (1.11–2.73) | |
| Female | 188 | 3 | 2.17 | 1.38 (0.28–4.04) | 7 | 3.22 | 2.17 (0.87–4.48) | 1 | 0.67 | 1.48 (0.02–8.25) | 3 | 0.32 | 9.37 (1.88–27.4) | 16 | 8.28 | 1.93 (1.10–3.14) | |
| Age at diagnosis | |||||||||||||||||
| <40 y | 241 | 0 | 0.54 | 0 (–) | 1 | 0.31 | 3.18 (0.04–17.7) | 0 | 0.05 | 0 (–) | 2 | 0.09 | 22.6 (2.54–81.8) | 3 | 2.32 | 1.29 (0.26–3.78) | |
| ⩾40 y | 117 | 11 | 4.83 | 2.28 (1.14–4.08) | 10 | 6.60 | 1.51 (0.73–2.79) | 3 | 1.35 | 2.22 (0.45–6.48) | 6 | 0.68 | 8.78 (3.21–19.1) | 33 | 16.6 | 1.99 (1.37–2.80) | |
| Disease location at diagnosis | |||||||||||||||||
| Ileal | 53 | 2 | 0.77 | 2.59 (0.29–9.34) | 1 | 0.84 | 1.20 (0.02–6.66) | 0 | 0.13 | 0 (–) | 0 | 0.10 | 0 (–) | 3 | 2.41 | 1.24 (0.25–3.63) | |
| Colonic | 151 | 5 | 2.76 | 1.81 (0.58–4.23) | 8 | 4.01 | 2.00 (0.86–3.93) | 3 | 0.86 | 3.49 (0.70–10.2) | 4 | 0.40 | 9.91 (2.67–25.4) | 21 | 10.2 | 2.05 (1.27–3.13) | |
| Ileocolonic | 134 | 4 | 1.71 | 2.35 (0.63–6.00) | 2 | 1.96 | 1.02 (0.11–3.69) | 0 | 0.40 | 0 (–) | 2 | 0.26 | 7.84 (0.88–28.3) | 10 | 5.83 | 1.72 (0.82–3.16) | |
| Upper GI | 20 | 0 | 0.13 | 0.00 (0.00–27.6) | 0 | 0.11 | 0 (–) | 0 | 0.02 | 0 (–) | 2 | 0.02 | 117 (13.1–422) | 2 | 0.42 | 4.76 (0.54–17.2) | |
| Disease behaviour at diagnosis | |||||||||||||||||
| Inflammatory | 264 | 10 | 3.68 | 2.71 (1.30–4.99) | 8 | 4.64 | 1.73 (0.74–3.40) | 2 | 0.91 | 2.21 (0.25–7.97) | 6 | 0.50 | 12.0 (4.39–26.2) | 28 | 12.7 | 2.20 (1.46–3.18) | |
| Stricturing | 57 | 1 | 1.11 | 0.90 (0.01–5.00) | 3 | 1.73 | 1.74 (0.35–5.08) | 1 | 0.34 | 2.91 (0.04–16.2) | 0 | 0.18 | 0 (–) | 6 | 4.37 | 1.37 (0.50–2.99) | |
| Penetrating | 30 | 0 | 0.56 | 0 (–) | 0 | 0.55 | 0 (–) | 0 | 0.15 | 0 (–) | 2 | 0.09 | 22.5 (2.52–81.1) | 2 | 1.77 | 1.13 (0.13–4.08) | |
| Penetrating and stricturing | 7 | 0 | 0.01 | 0 (–) | 0 | 0.01 | 0 (–) | 0 | 0.00 | 0 (–) | 0 | 0.00 | 0 (–) | 0 | 0.05 | 0 (–) | |
| Greece | |||||||||||||||||
| Heraklion | 15 | 21 | 3 | 0.40 | 7.52 (1.51–22.0) | 0 | 0.70 | 0 (–) | 1 | 0.09 | 11.3 (0.15–62.9) | 0 | 0.04 | 0 (–) | 4 | 1.53 | 2.61 (0.70–6.67) |
| Ioannina | 6 | ||||||||||||||||
| Italy | |||||||||||||||||
| Cremona | 10 | 42 | 0 | 1.02 | 0 (–) | 2 | 1.38 | 1.45 (0.16–5.25) | 0 | 0.19 | 0 (–) | 1 | 0.18 | 5.62 (0.07–31.3)) | 4 | 3.48 | 1.15 (0.31–2.94) |
| Reggio Emilia | 32 | ||||||||||||||||
| Israel (Beer Sheeva) | 21 | 0 | 0.17 | 0 (–) | 0 | 0.12 | 0 (–) | 0 | 0.02 | 0 (–) | 1 | 0.01 | 70.1 (0.92–390) | 1 | 0.49 | 2.03 (0.03–11.3) | |
| Portugal (Almada) | 13 | 0 | 0.14 | 0 (–) | 0 | 0.12 | 0 (–) | 0 | 0.03 | 0 (–) | 0 | 0.04 | 0 (–) | 0 | 0.49 | 0 (–) | |
| Spain (Vigo) | 33 | 1 | 0.49 | 2.05 (0.03–11.4) | 0 | 0.52 | 0 (–) | 0 | 0.19 | 0 (–) | 2 | 0.09 | 21.7 (2.44–78.5) | 3 | 1.77 | 1.70 (0.34–4.97) | |
| Denmark (Copenhagen) | 58 | 5 | 1.29 | 3.88 (1.25–9.05) | 3 | 1.52 | 1.98 (0.40–5.78) | 1 | 0.39 | 2.56 (0.03–14.3) | 1 | 0.20 | 4.89 (0.06–27.2) | 10 | 4.36 | 2.29 (1.10–4.22) | |
| Norway (Oslo) | 106 | 1 | 1.53 | 0.65 (0.01–3.63) | 5 | 2.64 | 1.89 (0.61–4.42) | 2 | 0.55 | 2.63 (0.41–13.1) | 1 | 0.20 | 5.09 (0.07–28.3) | 11 | 6.43 | 1.71 (0.85–3.06) | |
| the Netherlands (South Limburg) | 77 | 1 | 0.56 | 1.79 (0.02–9.97) | 1 | 0.39 | 2.56 (0.03–14.3) | 0 | 0.05 | 0 (–) | 2 | 0.05 | 37.8 (4.24–136) | 4 | 1.48 | 2.71 (0.73–6.94) | |
Thirteen patients with no known phenotype at diagnosis, of whom one female died due to pulmonary cause, were excluded from analysis in the age (<40 years and ⩾40 years), disease location, and disease behaviour at diagnosis categories. Three patients died due to other causes than listed (two infectious and one unknown).
No, number of patients; Exp, expected number of deaths; upper GI: upper gastrointestinal; SMR, standardised mortality ratio; 95% CI, 95% confidence interval; CCS, clinical classifications software; ICD, International Classification of Diseases.