Table 4 Treatment response, histological data, and metabolic risk factors in non‐obese and obese patients with chronic hepatitis C virus.
| Non‐obese (n = 54) | Obese (n = 12) | p Value | |
|---|---|---|---|
| Genotypes 1 and 4 | |||
| Response to treatment | |||
| RES | 29 (54%) | 1 (8%) | |
| NR | 25 (46%) | 11 (92%) | 0.004* |
| Cirrhosis on pretreatment biopsy | 10 (19%) | 6 (50%) | 0.024* |
| Steatosis | |||
| None | 31 (57%) | 1 (8%) | |
| Mild | 20 (37%) | 5 (42%) | |
| Moderate/severe | 3 (6%) | 6 (50%) | <0.001† |
| Glucose (mmol/l) | 4.74 (0.09) | 5.11 (0.46) | 0.46‡ |
| Insulin (mU/l) | 8.41 (1.41) | 14.63 (2.58) | 0.041‡ |
| C peptide (nmol/l) | 0.73 (0.10) | 1.14 (0.17) | 0.041‡ |
| HOMA | 1.75 (0.29) | 3.54 (1.05) | 0.026‡ |
| Non‐obese (n = 68) | Obese (n = 11) | p Value | |
|---|---|---|---|
| Genotypes 2 and 3 | |||
| Response to treatment | 55 (81%) | 7 (64%) | |
| RES | |||
| NR | 13 (19%) | 4 (36%) | 0.24* |
| Cirrhosis on pretreatment biopsy | 7 (13%) | 1 (9%) | 0.88* |
| Steatosis | |||
| None | 26 (38%) | 2 (18%) | |
| Mild | 25 (37%) | 2 (18%) | |
| Moderate/severe | 17 (25%) | 7 (64%) | 0.035† |
| Glucose (mmol/l) | 4.78 (1.46) | 4.81 (0.35) | 0.95‡ |
| Insulin (mU/l) | 7.42 (0.85) | 12.99 (3.23) | 0.13‡ |
| C peptide (nmol/l) | 0.62 (0.41) | 0.95 (0.17) | 0.080‡ |
| HOMA | 1.60 (0.17) | 3.06 (0.97) | 0.18‡ |
Data are mean (SEM).
NR, non‐response to antiviral treatment; RES, response to antiviral treatment; HOMA, homeostasis model of assessment.
*Fisher's exact test; †χ2 test; ‡Mann‐Whitney U test.