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. 2000 May 23;97(11):6085–6090. doi: 10.1073/pnas.97.11.6085

Figure 3.

Figure 3

Examples of chromosome 16p13 LOH analyses. The upper band of each allele is indicated with a line and the lost allele is indicated with an arrow. (A) Patient 487. Two alleles of the marker kg8 are present in normal kidney (NK) and normal lung (NL). Decreased intensity of the upper allele was found in the angiomyolipoma (A) and microdissected LAM specimen (L2) consistent with LOH. (B) Patient 490. Two alleles of the marker D16S525 are present in normal kidney and normal lung. Each allele is represented by a ladder of three or four bands, the highest of which is indicated with a line. Decreased intensity of the lower allele was found in the angiomyolipoma (A) and microdissected LAM specimen (L) consistent with LOH. (C) Patient 621. Two alleles of the marker D16S291 are present in normal kidney. Each allele is represented by two bands. Decreased intensity of the upper allele was found in the angiomyolipoma (A) consistent with LOH. (D) Patient 651. Two alleles of the marker D16S283 are seen in lymphoblastoid cells (LB), normal kidney, and normal lung. Each allele is represented by a ladder of three bands. Decreased intensity of the upper allele was seen in the angiomyolipoma (A) consistent with LOH. Decreased intensity of the upper allele was also seen in the LAM cells (L), suggestive of LOH.