Figure 1 Structure of connective tissue growth factor (CCN2) isoforms and their production by pancreatic stellate cells (PSC). (A) Recombinant CCN2 isoforms used in these studies. (B) CCN2 isoforms detected in PSC lysates or medium by radioimmunoprecipitation, sodium dodecyl sulphate‐polyacrylamide gel electrophoresis, and autoradiography of samples after labelling of cells with [35S]cysteine/methionine for six hours in the presence or absence of transforming growth factor β (TGF‐β1) 20 ng/ml. The major immunoreactive proteins (10, 20, 38 kDa) are indicated.