Table 3 Results of single locus analyses at OCTN1, OCTN2, and IGR2096C>A for 1104 inflammatory bowel disease (IBD) cases and 750 controls.
| Gene (variant) | Risk allele frequency (n (%)) | ORIBD (95% CI) | Genotype (n (%)) | ORIBD (95% CI) | PIBD (for association assuming multiplicative model) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IBD | UC | CD | Controls | IBD | UC | CD | Controls | |||||
| OCTN1 | 1027 | 473 | 471 | 616 | 1.31 | CC | 284 (26.2) | 131 (26.3) | 124 (25.3) | 261 (34.7) | 1.00 (ref) | 0.00010 |
| +1672 | (47.3) | (47.4) | (48.0) | (41.0) | (1.14–1.50) | CT | 575 (53.0) | 263 (52.7) | 263 (53.6) | 366 (48.7) | 1.44 (1.17–1.79) | |
| TT | 226 (20.8) | 105 (21.0) | 104 (21.2) | 125 (16.6) | 1.66 (1.26–2.19) | |||||||
| OCTN2 | 1124 | 526 | 510 | 695 | 1.31 | GG | 219 (20.5) | 98 (19.7) | 97 (20.1) | 211 (28.1) | 1.00 (ref) | 0.00014 |
| −207 | (52.5) | (52.9) | (52.8) | (46.3) | (1.14–1.50) | GC | 580 (54.2) | 272 (54.7) | 262 (54.2) | 385 (51.3) | 1.45 (1.15–1.82) | |
| CC | 272 (25.4) | 127 (25.6) | 124 (25.7) | 155 (20.6) | 1.69 [1.29–2.22) | |||||||
| IGR2230 | 1155 | 543 | 518 | 693 | 1.31 | CC | 229 (20.8) | 99 (19.4) | 105 (21.3) | 209 (27.8) | 1.00 (ref) | 0.00008 |
| (52.6) | (53.2) | (52.4) | (46.1) | (1.15–1.51) | CT | 585 (53.2) | 279 (54.7) | 260 (52.6) | 391 (52.1) | 1.37 (1.09–1.71) | ||
| TT | 285 (25.9) | 132 (25.9) | 129 (26.1) | 151 (20.1) | 1.73 (1.31–2.26) | |||||||
| IGR2096 | 1023 | 471 | 465 | 609 | 1.29 | CC | 288 (26.4) | 137 (27.2) | 124 (25.2) | 255 (34.4) | 1.00 (ref) | 0.00010 |
| (47.0) | (42.7) | (47.4) | (41.1) | (1.11–1.48) | CT | 579 (53.2) | 259 (51.6) | 269 (54.8) | 363 (49.0) | 1.41 (1.14–1.75) | ||
| TT | 222 (20.4) | 107 (21.2) | 98 (20.0) | 123 (16.6) | 1.61 (1.22–2.12) | |||||||
| IGR3096 | 1106 | 591 | 495 | 655 | 1.30 | TT | 250 (22.9) | 109 (21.5) | 116 (23.6) | 224 (30.1) | 1.00 (ref) | 0.00010 |
| IGR3096 | (50.6) | (51.3) | (50.4) | (44.0) | (1.14–1.49) | TC | 580 (53.1) | 275 (54.3) | 255 (51.9) | 385 (51.7) | 1.34 (1.08–1.68) | |
| CC | 263 (24.1) | 122 (24.1) | 120 (24.4) | 135 (18.1) | 1.74 (1.32–2.29) | |||||||
Genotype and allele frequencies are also given for the 496 individuals with Crohn's disease (CD) and the 512 individuals with ulcerative colitis (UC). Smoking and sex are included as confounders.