Table 3 Multiple Cox regression analysis of the influence of cytotoxic T lymphocyte antigen 4 (CTLA‐4) +49/+6230 haplotypes and patient characteristics stratified on centre on the rate of acute rejection.

	Risk ratio	95% CI	p Value
Haplotype +49A/+6230G (per allele number)	1.34	1.04–1.72	0.02
Diagnosis
Chronic viral hepatitis	1		0.01
Autoimmune related	2.05	1.24–3.35	<0.01
Alcoholic cirrhosis	1.34	0.75–2.39	0.33
FHF	2.25	1.23–4.14	0.01
Others	1.76	1.02–3.04	0.04

In the Cox regression model, each of the three different CTLA‐4 +49/+6230 haplotypes were included as a continuous variable, together with underlying liver disease, year of transplantation, and recipient ethnicity, sex, and age. The diagnosis group with a hazard ratio of 1 was chosen as the reference category. Only those parameters which were significantly associated with acute rejection are shown. The overall p value was 0.003 (log likelihood test).

FHF, fulminant hepatic failure; 95% CI, 95% confidence interval.