Table 4 Transmission disequilibrium testing results for IBD5 and OCTN variants in patients with inflammatory bowel disease.
| Mutation | IBD | CD | UC | |||
|---|---|---|---|---|---|---|
| χ2 | p Value | χ2 | p Value | χ2 | p Value | |
| IGR2230a_1 | 2.42 | 0.12 | 0.87 | 0.35 | 2.00 | 0.16 |
| IGR2198a_1 | 5.57 | 0.02 | 2.24 | 0.15 | 4.03 | 0.06 |
| IGR2096a_1 | 2.34 | 0.16 | 1.11 | 0.32 | 1.36 | 0.24 |
| IBD5 haplotype | 10.59 | 0.05 | 10.13 | <0.05 | 4.07 | 0.42 |
| OCTN1 | 7.54 | 0.01 | 4.21 | 0.04 | 3.54 | 0.06 |
| OCTN2 | 1.57 | 0.23 | 0.47 | 0.52 | 1.54 | 0.18 |
| TC haplotype | 12.92 | 0.01 | 6.59 | 0.11 | 7.72 | 0.21 |
The results were based on 293 patients with IBD, together with one or both parents (the numbers of informative trios were 271/197/74 for IBD/CD/UC, respectively). The results represented are for the allelic variants of the IBD5 marker single nucleotide polymorphisms IGR2096a_1, IGR2198a_1, and IGR2230a_1, the 1672C→T variant of the OCTN1 gene, and the −207G→C variant of the OCTN2 gene. The IBD5 haplotype in this table refers to the homozygosity for mutants of IGR2096a_1, IGR2198a_1, and IGR2230a_1 combined; the TC haplotype refers to homozygosity for the mutants of OCTN1/2 combined.
CD, Crohn's disease; IBD, inflammatory bowel disease; UC, ulcerative colitis.