Table 5 Allele frequencies and carriage rates for variants in the IBD5 haplotype in patients with inflammatory bowel disease compared with healthy controls.
| IBD patients (n = 299) v | p Value | Odds ratio | |
|---|---|---|---|
| healthy controls (n = 256) | |||
| Allelic frequency | |||
| IGR2096a_1 | 49.6% v 42.0% | 0.01 | 1.36 (1.07 to 1.73) |
| IGR2198a_1 | 48.4% v 41.0% | 0.01 | 1.35 (1.07 to 1.72) |
| IGR2230a_1 | 53.8% v 47.5% | 0.04 | 1.29 (1.01 to 1.64) |
| OCTN 1 | 50.0% v 42.9% | 0.02 | 1.33 (1.05 to 1.69) |
| OCTN 2 | 54.5% v 47.9% | 0.03 | 1.30 (1.03 to 1.66) |
| Homozygous carriage | |||
| IGR2096a_1 | 24.4% v 15.2% | 0.008 | 1.79 (1.16 to 2.78) |
| IGR2198a_1 | 22.8% v 15.2% | 0.03 | 1.64 (1.06 to 2.54) |
| IGR2230a_1 | 27.0% v 21.2% | 0.12 | 1.38 (0.92 to 2.05) |
| TC haplotype | 24.3% v 16.1% | 0.02 | 1.67 (1.08 to 2.58) |
| Combined IBD5 carriage | 21.3% v 14.7% | 0.06 | 1.57 (0.99 to 2.49) |
Three marker single nucleotide polymorphisms (SNPs) (IGR2096a_1, IGR2198a_1, and IGR2230a_1) were used to represent the IBD5 haplotype together with two SNPs in the OCTN1 and 2 (1672C→T and −207G→C, respectively). All five SNPs were associated with susceptibility to inflammatory bowel disease (IBD). Homozygous carriage of IGR2096a_1, IGR2198a_1, and the TC haplotype were associated with susceptibility to IBD. The results for heterozygous carriage all failed to achieve significance (results not shown).
IBD, inflammatory bowel disease.