Table 6 Allele frequencies and carriage rates for variants in the IBD5 haplotype in Crohn's disease patients compared with healthy controls.
| CD patients (n = 200) v | p Value | Odds ratio | |
|---|---|---|---|
| healthy controls (n = 256) | |||
| Allelic frequency | |||
| IGR2096a_1 | 49.2% v 42.0% | 0.04 | 1.34 (1.02 to 1.75) |
| IGR2198a_1 | 47.7% v 41.0% | 0.04 | 1.31 (1.01 to 1.71) |
| IGR2230a_1 | 53.8% v 47.5% | 0.06 | 1.29 (0.99 to 1.69) |
| OCTN 1 | 49.5% v 42.9% | 0.05 | 1.30 (1.00 to 1.70) |
| OCTN 2 | 54.8% v 47.9% | 0.04 | 1.32 (1.01 to 1.72) |
| Homozygous carriage | |||
| IGR2096a_1 | 23.6% v 15.2% | 0.03 | 1.72 (1.06 to 2.79) |
| IGR2198a_1 | 20.8% v 15.2% | 0.12 | 1.46 (0.90 to 2.38) |
| IGR2230a_1 | 26.9% v 21.2% | 0.16 | 1.37 (0.88 to 2.14) |
| TC haplotype | 22.2% v 16.1% | 0.11 | 1.48 (0.91 to 2.40) |
| Combined IBD5 haplotype | 19.2% v 14.7% | 0.42 | 1.38 (0.82 to 2.32) |
Three marker single nucleotide polymorphisms (SNPs) (IGR2096a_1, IGR2198a_1, and IGR2230a_1) were used to represent the IBD5 haplotype together with two SNPs in the OCTN1 and 2 (1672C→T and −207G→C, respectively). The three SNPs IGR2096a_1, IGR2198a_1, and −207G→C were associated with susceptibility to Crohn's disease. Homozygous carriage of the IGR2096a_1 was also associated with susceptibility to Crohn's disease. The results for heterozygous carriage all failed to achieve significance (results not shown).
CD, Crohn's disease.