Table 8 Comparison of patients and controls who are homozygous wild type for the IGR2198a_1 IBD5 haplotype marker single nucleotide polymorphism but have a risk allele in the TC haplotype.

	Subjects with no IBD5 risk alleles	Subjects with TC haplotype but no IBD5 risk alleles
Controls	82	10
IBD patients	72	5
χ2 p value comparing IBD patients with controls		0.27
CD patients	47	4
χ2 p value comparing CD patients with controls		0.57
UC patients	18	0
χ2 p value comparing UC patients with controls		0.20

The TC haplotype does not show an independent effect on disease susceptibility of the three IBD5 marker SNPs IGR2096a_1, IGR2198a_1, and IGR2230a_1, examined either individually or when combined in patients with IBD, Crohn's disease, or ulcerative colitis compared with controls. The data shown are only for IGR2198a_1, but results for all SNPs were non‐significant and are available on request.

CD, Crohn's disease; IBD, inflammatory bowel disease; SNP, single nucleotide polymorphism; UC, ulcerative colitis.