Table 1 Symptom severity before the run in period and before each treatment period.

	Visit 0 (before run in)	Visit 1 (before 1st treatment period)	Visit 4 (before 2nd treatment period)
Overall severity assessment	7.5 (0.3)	7.5 (0.3)	6.2 (0.6)*
No of days with impact on daily life	5.0 (0.2)	5.0 (0.2)	4.3 (0.3)*
Severity of impact on daily life	6.9 (0.3)	6.7 (0.4)	6.3 (0.5)
No of days abdominal pain	5.4 (0.2)	5.4 (0.2)	4.7 (0.3)*
Severity of abdominal pain	7.5 (0.3)	7.5 (0.3)	6.4 (0.6)
Worst episode of abdominal pain	8.5 (0.3)	8.4 (0.3)	6.7 (0.7)*
No of days bloating	4.9 (0.3)	4.8 (0.3)	4.2 (0.4)*
Severity of bloating	6.2 (0.5)	6.2 (0.5)	5.1 (0.6)*
Worst episode of bloating	7.3 (0.6)	7.1 (0.6)	6.3 (0.6)*
Severity of stool problems	6.3 (0.5)	6.4 (0.5)	6.3 (0.6)
No of days with loose stools	2.7 (0.4)	2.9 (0.4)	2.6 (0.4)
No of days with hard stools	2.0 (0.4)	2.0 (0.4)	2.0 (0.4)
No of days with urgency	2.6 (0.3)	2.6 (0.4)	2.4 (0.4)
No of days with straining	2.9 (0.4)	2.7 (0.4)	2.5 (0.4)*
No of days with incomplete evacuation	3.3 (0.4)	3.2 (0.41)	3.1 (0.4)

*Significantly different from visit 1 (p<0.05).