Figure 8 Characterisation of the Jak‐signal transducer and activator of transcription (STAT) pathway in Huh7 and Huh7 hepatitis C virus (HCV) replicon cell line. (A) Analysis of STAT1, STAT2, and STAT3 activation in Huh7 and Huh7 Core‐3′ cell lines treated with 50 U/ml of interferon (IFN)‐α2. (B) STAT1 tyrosine phosphorylation (tyr) in Huh7 and Huh7 genomic HCV replicon (Core‐3′) cell lines after treatment with 50 U/ml of IFN‐γ. (C) STAT1 and STAT3 activation in Huh7 and Huh7 genomic HCV replicon (Core‐3′) cell lines after treatment with 50 ng/ml of cardiotrophin 1 (CT‐1). (D) HCV replication in Huh7 genomic HCV replicon cell line pretreated with AG490 and then stimulated with IFN‐α (50 U/ml) for 48 hours.