Table 1 Cumulative cancer risk by site, age, and sex in Peutz‐Jeghers syndrome LKB1 gene mutation carriers.
| Type of cancer (n out of total or by sex) | Cancer risk by age (y) (95% CL) | |||||
|---|---|---|---|---|---|---|
| 20 | 30 | 40 | 50 | 60 | 70 | |
| All cancers (32 in 149 total) | 1% (0–2) | 6% (1–10) | 18% (9–26) | 31% (18–41) | 41% (26–53) | 67% (31–84) |
| All cancers (13 in 76 males) | 1% (0–4) | 5% (0–11) | 10% (1–18) | 24% (8–38) | 39% (16–56) | 55% (13–76) |
| All cancers (19 in 73 females) | – | 6% (0–13) | 27% (11–40) | 39% (19–54) | 45% (22–61) | 59% (20–79) |
| Gastrointestinal (22 in 149 total) | 1% (0–2) | 4% (0–8) | 12% (5–19) | 24% (12–35) | 34% (18–46) | 63% (23–82) |
| Gastrointestinal (12 in 76 males) | 1% (0–4) | 5% (0–11) | 10% (1–18) | 24% (8–38) | 36% (13–53) | 52% (9–75) |
| Gastrointestinal (10 in 73 females) | – | 2% (0–7) | 14% (2–26) | 24% (6–39) | 31% (9–48) | 48% (3–73) |
| Gynaecological (7 in 73 females) | – | 4% (0–9) | 13% (1–24) | 18% (3–32) | – | – |
| Breast (1 in 73 females) | – | – | 5% (0–13) | – | – | – |
| Other (2 in 149 total) | – | – | – | – | 3% (0–9) | 27% (0–59) |
| Other (1 in 76 men) | – | – | – | – | 6% (0–16) | – |
| Other (1 in 73 women) | – | – | – | – | – | – |
95% CL, 95% confidence limits.
–, not estimable.