Table 4 Cancer risk differences in Peutz‐Jeghers syndrome patients between LBK1 exon 3 or exon 6 mutation (+ or −) subgroups.

Exon	Sex	No of cancers of each type (% of subgroup) by LKB1 exon 3 or exon 6 mutation status (+ or −)
		All cancers		Gastrointestinal		Gynaecological		Breast		Other
		+	−	+	−	+	−	+	−	+	−
3	Overall	6 (30%)	23 (18%)	6 (30%)	16 (12%)	–	–	–	–	1 (5%)	1 (1%)
		p = 0.74		p = 0.30		–		–		p = 0.22
	Males	3 (30%)	10 (15%)	3 (10%)	9 (14%)	–	–	–	–	0 (0%)	1 (2%)
		p = 0.26		p = 0.21		–		–		p = 0.74
	Females	3 (30%)	13 (21%)	3 (10%)	7 (11%)	2 (10%)	5 (8%)	0 (0%)	1 (2%)	1 (10%)	0 (0%)
		p = 0.53		p = 0.91		p = 0.81		p = 0.59		p = 0.32
6	Overall	3 (43%)	26 (18%)	2 (29%)	20 (14%)	–	–	–	–	0 (0%)	2 (1%)
		p = 0.022		p = 0.079		–		–		p = 0.86
	Males	1 (33%)	12 (16%)	1 (33%)	11 (15%)	–	–	–	–	0 (0%)	1 (1%)
		p = 0.56		p = 0.49		–		–		p = 0.82
	Females	2 (50%)	14 (20%)	1 (25%)	9 (13%)	1 (25%)	6 (9%)	0 (0%)	1 (1%)	0 (0%)	1 (1%)
		p = 0.0000084		p = 0.00030		p = 0.0055		NE		NE

NE, not estimable.