Table 1 Demographics of the UK cohorts and comparison with previously reported Dutch cohorts.
| UK coeliac cases | Dutch coeliac cases* | UK healthy controls | UK population controls | Dutch controls† | |
|---|---|---|---|---|---|
| No of individuals | 375 | 463 | 371 | 995 | 686 |
| Female (%) | 73% | 69% | 48%‡ | 50% | 49% |
| Age (y) (at Dec 2005) (median (range)) | 55 (17–86) | 44 (3–93) | na (all >16) | 48 (48–48) | 48 (6–93) |
| Age at diagnosis (y) (median (range)) | 42 (0–78) | 35 (1–83) | |||
| HLA‐DQ2 positive (%) (possession of DQA1*05 + DQB1*02 heterodimer) | 94%§ | 94% | na | na | na |
| Small intestinal villous atrophy (%) (at diagnosis, Marsh III lesion) | 100% | 100% | |||
| IgA antiendomysial/tTG antibody status (%) | ¶ | ||||
| Known positive (when untreated) | 70.6% | na | |||
| Not performed when untreated | 28.2% | ||||
| Known IgA deficiency | 1.2% |
*Combined cases set 1 and 2 from Dutch study.4
†Combined controls set 1 and 2 from Dutch study.4
‡Data available on 134 of 371 UK healthy controls, others mostly anonymous blood donors.
§Data available on 249 of 375 UK cases.
¶Serology data available for 344 of 375 UK coeliac cases.
na, not available; tTG, tissue transglutaminase; HLA, human leucocyte antigen.