Table 2 Sex and frequency of CpG island methylator phenotype (CIMP).

Cohort	No of methylated loci						CIMP
	0	1	2	3	4	5	⩾4
Men	77	40	22	13	7	13	20/172 (12%)*
Women	136	46	30	18	22	36	58/288 (20%)*

Cases of men were derived from the Health Professional Follow up Study (n = 51 500 men) and cases of women were from the Nurses' Health Study (n = 121 700 women).

*Men versus women, p = 0.02.