Table 5 Microsatellite instability, KRAS and BRAF status, and frequency of CpG island methylator phenotype (CIMP).
| MSI status | KRAS | BRAF | No of methylated loci | CIMP | |||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | ⩾4 | |||
| MSI‐H | Mutant | Wild‐type | 3 | 2 | 1 | 0 | 0 | 1 | 1/7 (14%)*† |
| Wild‐type | Mutant | 0 | 0 | 0 | 0 | 7 | 27 | 34/34 (100%)*‡ | |
| Wild‐type | Wild‐type | 7 | 2 | 1 | 0 | 4 | 15 | 19/29 (66%)†‡ | |
| MSS | Mutant | Wild‐type | 49 | 32 | 18 | 9 | 4 | 0 | 4/112 (3.6%)§ |
| Wild‐type | Mutant | 5 | 1 | 6 | 5 | 7 | 0 | 7/24 (29%)§¶ | |
| Wild‐type | Wild‐type | 85 | 28 | 15 | 5 | 2 | 0 | 2/135 (1.5%)¶ | |
MSI‐H, microsatellite instability‐high; MSI‐L, microsatellite instability‐low; MSS, microsatellite stable.
*KRAS mutant versus BRAF mutant, p = 2×10−6; †KRAS mutant versus both wild‐types, p = 0.03; ‡BRAF mutant versus both wild‐types, p = 0.0002; §KRAS mutant versus BRAF mutant, p = 0.0005; ¶BRAF mutant versus both wild‐types, p = 2×10−5.