Table 2 Intragastric pH in mice with either a sham operation or oesophagitis.

Genotype	Operation	Drug	Intragastric pH
VR‐1 (+/+)	Sham		6.12 (0.89)
VR‐1 (−/−)	Sham		5.98 (0.95)
VR‐1 (+/+)	Oesophagitis		2.15 (0.43)
VR‐1 (−/−)	Oesophagitis		2.28 (0.33)
VR‐1 (+/+)	Oesophagitis	Famotidine	4.23 (1.53)**
VR‐1 (+/+)	Oesophagitis	Omeprazole	5.81 (0.35)**
VR‐1 (+/+)	Oesophagitis	Capsazepine	4.33 (0.80)**

VR‐1, vanilloid receptor subtype 1.

A subset of mice were administered famotidine, omeprazole, or capsazepine. Note that sham operated mice did not have a significant reduction in intragastric pH, while both (+/+) and (−/−) mice with oesophagitis had a significant reduction in pH. Note the increase in pH levels following antisecretory and VR‐1 antagonism therapy.

Values are mean (SD).

**p<0.01 compared with VR‐1 (+/+).