Table 1 Clinical feature of mucosa associated lymphoid tissue (MALT) lymphoma with t(1;14)(p22;q32) or variants.

Case No	Age	Sex	Primary site	Genetic investigations	BCL10 involved chromosomal translocation	BCL10 IHC	Staging*	Dissemination	Clinical follow up
18	71	M	Stomach	Karotyping, interphase FISH, molecular cloning	t(1;14)(p22;q32)	Strong nuclear staining	IVE	Perigastric lymph nodes, omentum, spleen, pleural effusion, blood	n/a
2	48	F	Stomach	Karotyping, interphase FISH	t(1;14)(p22;q32)	n/a	IVE	Perigastric and splenic hilus lymph nodes, pleural involvement, bone marrow involvement?	4 cycles of MCP chemotherapy, partial remission, alive at two year follow up
3	67	M	Stomach	Karotyping, interphase FISH	t(1;2)(p22;q12)	Strong nuclear staining	IIIE	Perigastric lymph nodes and spleen	Chemotherapy with chlorambucil, complete remission in three year follow up
4	73	F	Stomach	Interphase FISH	Yes	Strong nuclear staining	IIIE	Perigastric and mesenteric lymph nodes,	Low dose chlorambucil chemotherapy, complete remission at 1.5 year follow up
5	49	M	Stomach	Interphase FISH	Yes	Strong nuclear staining	IVE	Lung	n/a
6	n/a	n/a	Stomach	Karotyping, interphase FISH	t(1;14)(p22;q32)	Strong nuclear staining	IIE	n/a	n/a
79	63	F	Lung	Karotyping, interphase FISH	t(1;14)(p22;q32)	n/a	IVE	Blood, bilateral pulmonary involvement, pleural and ascitic effusions, retroperitoneal lymph node	8 year low grade B cell lymphoma, then presented an aggressive clinical course presenting with lymphocytosis, pleural and ascitic effusions, partially response to chemotherapy, died of disease
89	49	F	Lung	Karotyping, interphase FISH	t(1;14)(p22;q32)	n/a	IIE	n/a	n/a
9	57	F	Lung	Interphase FISH	IGH‐BCL10 fusion	Strong BCL10 nuclear staining	IE	No clinical evidence	Data on treatment not available, but patients alive without evidence of disease for 16 years
10	32	F	Breast	Karotyping, interphase FISH	t(1;14)(p22;q32)	n/a	IIE	Axillary lymph nodes	6 cycles of CHOP therapy followed by surgery, complete remission in two year follow up
11	75	F	Breast	Interphase FISH	IGH‐BCL10 fusion	Strong BCL10 nuclear staining	IE	No clinical evidence	n/a

*Ann Arbor‐Musshoff staging system for extranodal lymphoma; the clinical stage was likely to have been underestimated as appropriate staging was unlikely to be carried out in each of these archival cases.

IHC, immunohistochemistry; FISH, fluorescence in situ hybridisation; n/a, not available.