Replication of KOS, Δtk, Δvhs, 17Δtk, and 17ΔtkR in corneas and trigeminal ganglia. Replication in corneas is shown for KOS (closed squares), Δtk (open triangles), and Δvhs (open circles) in wild-type 129 mice (A), IFN-αβγR−/− mice (B), and PKR-deficient mice (C). (D) Growth in trigeminal ganglia of wild-type 129, PKR-deficient, and IFN-αβγ receptor-deficient mice of KOS (solid bars), Δtk (shaded bars), and Δvhs (open bars). Replication in corneas is also shown for 17Δtk (open triangles) and 17ΔtkR (closed squares) in wild-type 129/B6 mice (E) and PKR−/− mice (F). (G) Growth in trigeminal ganglia of wild-type 129/B6 and PKR-deficient mice of 17ΔtkR (shaded bars) and 17Δtk (solid bars). Values shown are logarithmic means from four to six samples (± SEM). Δtk and Δvhs are in the background of strain KOS. 17Δtk and 17ΔtkR are in the background of strain 17.