Table 2 Odds of cases compared with controls showing evidence of staining for markers in the initial oesophageal biopsies.
| Marker | †Oesophageal malignancy and high grade dysplasia | Oesophageal malignancy | Oesophageal adenocarcinoma | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR (95% CI) | Cases | Controls | OR (95% CI) | Cases | Controls | OR (95% CI) | |
| Cyclin D1 | |||||||||
| None | 5 | 29 | 1.00 | 4 | 19 | 1.00 | 3 | 17 | 1.00 |
| Focal | 19 | 70 | 1.66 (0.44, 6.20) | 15 | 58 | 1.14 (0.30, 4.28) | 11 | 44 | 1.26 (0.27, 5.81) |
| Diffuse/intense | 10 | 64 | 0.93 (0.21, 4.22) | 9 | 59 | 0.65 (0.14, 2.94) | 8 | 47 | 0.81 (0.14, 4.58) |
| Diffuse/intense v none/focal | 0.59 (0.24, 1.48) | 0.58 (0.22, 1.52) | 0.66 (0.22, 1.99) | ||||||
| TP53 | |||||||||
| None | 13 | 85 | 1.00 | 10 | 66 | 1.00 | 8 | 60 | 1.00 |
| Focal | 10 | 59 | 1.65 (0.59, 4.63) | 8 | 53 | 1.48 (0.47, 4.68) | 6 | 34 | 1.57 (0.43, 5.67) |
| Diffuse/intense | 11 | 19 | 8.42 (2.37, 30.0) | 10 | 17 | 11.1 (2.32, 52.7) | 8 | 14 | 11.7 (1.93, 71.4) |
| Diffuse/intense v none/focal | 6.34 (2.11, 19.1) | 8.59 (2.22, 33.3) | 9.28 (1.78, 48.3) | ||||||
| COX‐2 | |||||||||
| None | 7 | 28 | 1.00 | 6 | 22 | 1.00 | 5 | 19 | 1.00 |
| Grade 1 | 18 | 106 | 0.72 (0.25, 2.08) | 14 | 90 | 0.58 (0.18, 1.87) | 11 | 74 | 0.53 (0.15, 1.83) |
| Grade 2/3 | 9 | 28 | 1.62 (0.36, 7.30) | 8 | 23 | 1.65 (0.30, 9.05) | 6 | 14 | 1.68 (0.26, 10.7) |
| Grade 2/3 v grade 0/1 | 2.22 (0.72, 6.79) | 2.78 (0.77, 9.95) | 3.03 (0.71, 12.9) | ||||||
| β‐catenin | |||||||||
| None | 21 | 105 | 1.00 | 15 | 85 | 1.00 | 11 | 67 | 1.00 |
| Focal | 11 | 54 | 1.05 (0.45, 2.44) | 11 | 42 | 1.33 (0.54, 3.28) | 9 | 37 | 1.46 (0.55, 3.95) |
| diffuse/intense | 1 | 2 | 2.40 (0.19, 29.7) | 1 | 2 | 2.43 (0.20, 30.3) | 1 | 2 | 2.22 (0.17, 28.1) |
| Diffuse/intense v none/focal | 2.37 (0.19, 29.2) | 2.27 (0.18, 28.0) | 2.04 (0.16, 25.8) | ||||||
†Oesophageal malignancy refers to adenocarcinomas and patients with undifferentiated/unspecified carcinoma.
Reference category in each analysis is no staining.
COX‐2, cyclooxygenase 2; OR (95% CI), odds ratio (95% confidence interval).