Table 1 Expression of angiogenic factors in colorectal carcinoma: association with clinical features.
| Factor | No of patients | Association | Reference |
|---|---|---|---|
| VEGF | |||
| 52 | +MVD, +metastasis, +proliferation index | Takahashi64 | |
| 100 | +MVD, +Dukes grade | Nakasaki66 | |
| 152 | −Differentiation, +lymphatic metastasis, | ||
| +hepatic metastasis, +advanced stage | Ochiumi94 | ||
| 163 | +MVD, −prognosis, +hepatic metastasis | Kang197 | |
| 136 | +MVD, −prognosis, +TP expression | Amaya198 | |
| 100 | +MVD, −prognosis, +hepatic metastasis | Maeda199 | |
| 121 | +Recurrence rate | Cascinu200 | |
| 259 | +MVD, +liver metastasis, −mean survival | Harada201 | |
| 152 | −Mean survival | Kaio202 | |
| PD‐ECGF | |||
| (thymidine phosphorylase) | 163 | +MVD, +tumour size, +advanced stage, | Takebayashi 203 |
| +lymphatic metastasis, −prognosis | |||
| 86 | −Lymphatic/haematogenous metastasis | Saito204 | |
| 32 | −Mean survival | van Triest205 | |
| 148 | −Prognosis | Matsumura206 | |
| HIF | |||
| 149 | +MVD, +advanced stage, +hepatic metastasis, | ||
| +VEGF expression | Kuwai101 | ||
| 87 | +MVD, −mean survival, +COX‐2 expression | Yoshimura102 |
VEGF, vascular endothelial growth factor; PD‐ECGF, platelet derived endothelial cell growth factor; HIF, hypoxia inducible factor; MVD, microvascular density.
NS, no significant correlation; +, positively correlated; −, inversely correlated.