Table 1 Effect of duodenal glucose perfusion on blood glucose and plasma immunoreactivities of gastrointestinal peptides with and without intravenous exendin(9‐39)NH2.
| Intravenous infusion | Duodenal glucose perfusion rate (60 min each) | |||||
|---|---|---|---|---|---|---|
| 1 kcal/min | 2.5 kcal/min | 2.5 kcal/min (recovery) | ||||
| Saline iv | Ex(9‐39) | Saline iv | Ex(9‐39) | Saline iv | Saline iv | |
| GLP‐1 (pmol/l/60 min) | −0.5 (1.3) | −0.4 (1.5) | 13 (4.5) | 29 (7.4)* | 25 (5.5) | 30 (10) |
| GIP (pg/ml/60 min) | 247 (52) | 337 (90) | 801 (116) | 904 (121) | 1319 (166) | 1151 (93) |
| Blood glucose (mmol/l/60 min) | 6.4 (0.5) | 8.3 (0.9)* | 13 (1.1) | 18 (1.6)* | 7.4 (1.0) | 9.2 (1.3) |
| Insulin (mU/l/60 min) | 62 (8.3) | 54 (9.5) | 287 (40) | 220 (38)* | 194 (27) | 195 (35) |
| C‐peptide (ng/ml/60 min) | 9.1 (0.7) | 7.6 (0.8) | 34 (5.8) | 28 (4.9) | 31 (5.0) | 33 (6.7) |
| Glucagon (pg/ml/60 min) | −80 (11) | 15 (16)* | −138 (25) | 5.4 (23)* | −156 (31) | −46 (25)* |
iv, intravenous; GLP‐1, glucagon‐like peptide 1; GIP, glucose dependent insulinotropic polypeptide.
Mean (SEM) of AUC over basal during each 60 minute perfusion period (n = 9). Differences were compared using two way repeated measures ANOVA employing individual incremental or decremental values over basal during the respective periods.
*p<0.05 versus saline iv.