Table 3 Effects of intravenous exendin(9‐39)NH2 on antro‐pyloro‐duodenal motility during duodenal glucose perfusion at different rates.
| IV infusion | Duodenal glucose perfusion rate (60 min each) | |||||
|---|---|---|---|---|---|---|
| 1 kcal/min | 2.5 kcal/min | 2.5 kcal/min (recovery) | ||||
| Saline iv | Ex(9‐39) | Saline iv | Ex(9‐39) | Saline iv | Saline iv | |
| Antral motility | ||||||
| Pressure waves (No/60 min) | 13 (3.3) | 46 (7.5)* | 8.0 (2.6) | 16 (3.7)* | 24 (6.3) | 20 (4.7) |
| Motility index (mm Hg×s/60 min) | 4498 (1622) | 9954 (2645)* | 364 (144) | 1016 (250)* | 1549 (461) | 2372 (901) |
| Amplitude (mm Hg) | 49 (11) | 49 (6.9) | 21 (4.0) | 25 (6.2) | 31 (6.8) | 37 (7.7) |
| Duodenal motility | ||||||
| Pressure waves (No/60 min) | 141 (10) | 195 (17)* | 74 (12) | 151 (11)* | 131 (20) | 143 (17) |
| Motility index (mmHg×s/60 min) | 7118 (1278) | 9785 (1376)* | 3463 (612) | 5711 (804)* | 5416 (982) | 5776 (877) |
| Amplitude (mm Hg) | 23 (0.8) | 24 (1.5) | 21 (2.0) | 22 (1.7) | 22 (1.9) | 24 (1.2) |
| Pyloric motility | ||||||
| IPPW (No/60 min) | 26 (5.5) | 14 (2.7) | 53 (9.5) | 24 (6.2)* | 47 (9.2) | 28 (8.1)* |
| Pyloric tone (mm Hg) | 6.2 (1.0) | 5.0 (0.8) | 9.8 (1.3) | 5.8 (1.1)* | 11 (1.5) | 6.3 (1.3)* |
IPPW, isolated pyloric pressure waves; iv, intravenous.
Mean (SEM) of actual values and of values over basal (pyloric tone) during each 60 minute perfusion period. Values for pressure waves and motility indices represent the sum of two antral and three duodenal side holes, respectively (n = 9).
Differences were compared using two way repeated measures ANOVA employing individual incremental or decremental values during the respective periods.
*p<0.05 versus saline iv.