Table 1.

Transgenic lines and lesions

Line	Founder	Total no.	Phenotypic lesions*
29	Male	19†	H ++++, R +++, A +++
33	Male	5	H ++, R ++, A ++
105	Female	4	H ++, R ++, A ++
120	Male	4	H ++, R ++, A +++
150	Male	1	H ++++, R ++, A ++
180	Female	3	H +, R +, A +++

^*Lesions were ranked as follows: hyperplasia (H): +, mild; ++, moderate with dermal extension; +++, moderate to severe with dysplasia; ++++, extensive with dysplasia, and ulceration. Runting (R): +, body wt. 85–90% of siblings; ++, body wt. 75–84% of siblings; +++, body wt. 50–75% of siblings. Alopecia (A): ++, hair loss 20–45%; +++, hair loss 45–75%. Sporadic lesions included toenail hyperkeratosis, dilated sex glands, and lymphoid hyperplasia. 

^†F₁ and F₂ generations.