Figure 7 Bethanechol dose–response curves of jejunal circular smooth‐muscle contractile activity. Intestinal manipulation (IM, ▴); reduces muscle function compared with controls (•). Depletion and inactivation of macrophages (macrophage‐depleted and inactivated rats (DI rats)) prevent the surgical‐induced suppression and normalised the contractility (▪). Values are displayed as means (SD; n = 5). KRB, Krebs–Ringer buffer.