Figure 1 In control rats, normal histological colon morphology is evident (A, ×20). Seventy two hours after induction of trinitrobenzene sulphate (TNBS) colitis, severe transmural infiltration of the colon wall developed, with submucosal oedema, lymphocytic and neutrophilic infiltration, coagulative necrosis and perivascular fibrosis (B, ×10). Histological study of the gastric fundus showed a normal microscopic anatomy with no apparent differences between control rats (C, ×20) and rats with TNBS colitis (D, ×20). All sections were stained with haematoxylin‐eosin.