Table 1 Baseline characteristics of the internal and external cohort.
| Variable | Internal cohort (Bologna) n = 251 | External cohort (London) n = 137 | p Value |
|---|---|---|---|
| Demographic | |||
| Age (years) | 51.7 (8.5) | 50.5 (12.5) | 0.345 |
| Sex (male) | 206 (82%) | 97 (71%) | 0.015 |
| Indication for LT | |||
| Hepatitis B or C cirrhosis | 196 (78.1%) | 86 (62.8%) | 0.001 |
| Alcoholic liver disease | 37 (14.7%) | 19 (13.9%) | |
| Primary cholestatic disease* | 18 (7.2%) | 32 (23.4%) | |
| Laboratory values | |||
| AST (IU/l) | 97.2 (75.6) | 89.4 (72.6) | 0.369 |
| Total bilirubin (mg/dl) | 4.7 (3.4) | 4.8 (3.3) | 0.780 |
| GGT (IU/l) | 72.1 (68.4) | 169.7 (119.4) | 0.001 |
| ALP (IU/l) | 348.8 (207.0) | 272.0 (232.8) | 0.015 |
| Creatinine (mg/dl) | 0.94 (0.23) | 1.36 (1.02) | 0.001 |
| Albumin (g/dl) | 3.1 (0.5) | 3.0 (0.7) | 0.130 |
| INR | 1.65 (0.40) | 1.28 (0.50) | 0.001 |
| Platelet count (×103/mm3) | 73.2 (51.8) | 143.3 (128.5) | 0.001 |
| WBC (×103/mm3) | 4.5 (1.7) | 5.2 (1.9) | 0.276 |
| Haemoglobin (g/dl) | 11.8 (5.3) | 11.1 (2.1) | 0.093 |
| MELD score | 16.7 (4.8) | 14.7 (6.9) | 0.003 |
ALP, alkaline phosphatase; AST, aspartate aminotransferase; GGT, γ‐glutamyl‐transpeptidase; INR, international normalised ratio; LT, liver transplantation; MELD, model for end‐stage liver disease; WBC, white cell.
Continuous variables are reported as mean (SD).
*Included primary biliary cirrhosis and primary sclerosing cholangitis.